The multiple layers of redundancy would likely clash with Adnauseum, yeah. Although that probably is just wasted compute - you may only need one or two of those solutions to have effective adblocking (uBlock for supported browsers, pi.hole for devices unable to have uBlock installed) rather than all 3 at once.
All clicks are performed in an isolated sandbox separate from the user area (basically imagine the click register signal going out, but nothing more).
What if you have a multi layered ad blocking setup where you’re using ublock origin and pi.hole and a VPN with blocking?
The multiple layers of redundancy would likely clash with Adnauseum, yeah. Although that probably is just wasted compute - you may only need one or two of those solutions to have effective adblocking (uBlock for supported browsers, pi.hole for devices unable to have uBlock installed) rather than all 3 at once.