The multiple layers of redundancy would likely clash with Adnauseum, yeah. Although that probably is just wasted compute - you may only need one or two of those solutions to have effective adblocking (uBlock for supported browsers, pi.hole for devices unable to have uBlock installed) rather than all 3 at once.
That seems like it opens the door to a lot of security issues. Part of the reason to use uBlock is that ads are a known threat vector.
All clicks are performed in an isolated sandbox separate from the user area (basically imagine the click register signal going out, but nothing more).
What if you have a multi layered ad blocking setup where you’re using ublock origin and pi.hole and a VPN with blocking?
The multiple layers of redundancy would likely clash with Adnauseum, yeah. Although that probably is just wasted compute - you may only need one or two of those solutions to have effective adblocking (uBlock for supported browsers, pi.hole for devices unable to have uBlock installed) rather than all 3 at once.